Our laboratory studies how cytoskeleton-derived signals control stem cells' ability to give rise to a functional tissue during development, maintain it throughout life, and repair it upon wounding.
The actin cytoskeleton is a complex cellular structure that plays a role in many biological processes. Classic studies established its role in cell structural organization. However, new studies demonstrate that the actin cytoskeleton plays a major role in regulatory processes that control signal transduction, gene expression, and stem cell lineage specification.
Our laboratory uses the skin epidermis as its main model system. Projects in the lab explore both skin development and skin common diseases such as cancer and psoriasis.
In addition to classic genetic tools and in vivo models, we also use state of the art technology to manipulate stem cells in utero. Genome-wide analysis of gene expression, quantitative digital microscopy, and various molecular and cellular methods are all commonly used in our lab.
for additional details, see our recent publications: